{"id":1638,"date":"2025-06-27T16:47:29","date_gmt":"2025-06-27T16:47:29","guid":{"rendered":"https:\/\/tiengduc1kem1.edu.vn\/index.php\/2025\/06\/27\/2723-kham-pha-cac-phuong-phap-mien-dich-te-bao-nk-t-va-vaccine-dc-buoc-tien-moi-trong-dieu-tri-ung-thu\/"},"modified":"2025-06-27T16:47:29","modified_gmt":"2025-06-27T16:47:29","slug":"2723-kham-pha-cac-phuong-phap-mien-dich-te-bao-nk-t-va-vaccine-dc-buoc-tien-moi-trong-dieu-tri-ung-thu","status":"publish","type":"post","link":"https:\/\/tiengduc1kem1.edu.vn\/index.php\/2025\/06\/27\/2723-kham-pha-cac-phuong-phap-mien-dich-te-bao-nk-t-va-vaccine-dc-buoc-tien-moi-trong-dieu-tri-ung-thu\/","title":{"rendered":"Kh\u00e1m ph\u00e1 c\u00e1c ph\u01b0\u01a1ng ph\u00e1p mi\u1ec5n d\u1ecbch t\u1ebf b\u00e0o NK, T v\u00e0 vaccine DC: B\u01b0\u1edbc ti\u1ebfn m\u1edbi trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0"},"content":{"rendered":"

T\u00f3m t\u1eaft:<\/strong> B\u00e0i vi\u1ebft n\u00e0y s\u1ebd gi\u00fap b\u1ea1n hi\u1ec3u r\u00f5 c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng, \u1ee9ng d\u1ee5ng l\u00e2m s\u00e0ng v\u00e0 ti\u1ec1m n\u0103ng c\u1ee7a c\u00e1c li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch t\u1ebf b\u00e0o nh\u01b0 NK, CAR\u2011T\/TCR\u2011T v\u00e0 vaccine t\u1ebf b\u00e0o DC. B\u00e0i vi\u1ebft \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf theo m\u00f4 h\u00ecnh SPIN \u2013 gi\u00fap ng\u01b0\u1eddi \u0111\u1ecdc nh\u1eadn di\u1ec7n r\u00f5 t\u00ecnh hu\u1ed1ng, v\u1ea5n \u0111\u1ec1, h\u1ec7 qu\u1ea3 v\u00e0 nhu c\u1ea7u th\u1ef1c s\u1ef1 khi ti\u1ebfp c\u1eadn c\u00e1c li\u1ec7u ph\u00e1p m\u1edbi trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0.<\/p>\n

<\/p>\n

Kh\u00e1m ph\u00e1 Li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch SETAVN<\/a><\/p>\n

\ud83e\uddec S \u2013 Situation (T\u00ecnh hu\u1ed1ng hi\u1ec7n t\u1ea1i):<\/strong> Li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch ng\u00e0y c\u00e0ng \u0111\u01b0\u1ee3c quan t\u00e2m<\/h3>\n

Trong nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y, c\u00e1c c\u1ee5m t\u1eeb nh\u01b0:<\/p>\n

    \n
  1. <\/span>\u201cTr\u1ecb ung th\u01b0 b\u1eb1ng t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch\u201d<\/li>\n
  2. <\/span>\u201cC\u00e1ch ho\u1ea1t \u0111\u1ed9ng c\u1ee7a vaccine t\u1ebf b\u00e0o DC\u201d<\/li>\n
  3. <\/span>\u201cCAR\u2011T ch\u1eefa kh\u1ecfi ung th\u01b0 kh\u00f4ng?\u201d<\/li>\n<\/ol>\n

    …\u0111ang \u0111\u01b0\u1ee3c t\u00ecm ki\u1ebfm r\u1ed9ng r\u00e3i. \u0110i\u1ec1u n\u00e0y cho th\u1ea5y m\u1ed1i quan t\u00e2m ng\u00e0y c\u00e0ng l\u1edbn t\u1eeb c\u1ed9ng \u0111\u1ed3ng b\u1ec7nh nh\u00e2n v\u00e0 ng\u01b0\u1eddi th\u00e2n v\u1ec1 c\u00e1c li\u1ec7u ph\u00e1p nh\u01b0:<\/p>\n

      \n
    1. <\/span>T\u1ebf b\u00e0o NK \u2013 s\u00e1t th\u1ee7 t\u1ef1 nhi\u00ean<\/li>\n
    2. <\/span>T\u1ebf b\u00e0o T t\u00e1i l\u1eadp theo c\u00f4ng ngh\u1ec7 cao<\/li>\n
    3. <\/span>Li\u1ec7u ph\u00e1p hu\u1ea5n luy\u1ec7n h\u1ec7 mi\u1ec5n d\u1ecbch<\/li>\n<\/ol>\n

      \u26a0\ufe0f P \u2013 Problem (V\u1ea5n \u0111\u1ec1):<\/strong> Hi\u1ec3u nh\u1ea7m gi\u1eefa k\u1ef3 v\u1ecdng v\u00e0 th\u1ef1c t\u1ebf<\/h3>\n

      D\u00f9 th\u00f4ng tin tr\u00e0n lan, nh\u01b0ng nhi\u1ec1u ng\u01b0\u1eddi v\u1eabn:<\/p>\n

        \n
      1. <\/span>Tin r\u1eb1ng NK thay th\u1ebf \u0111\u01b0\u1ee3c h\u00f3a tr\u1ecb<\/li>\n
      2. <\/span>Nh\u1ea7m l\u1eabn CAR\u2011T v\u1edbi thu\u1ed1c \u0111\u1eb7c tr\u1ecb<\/li>\n
      3. <\/span>Cho r\u1eb1ng vaccine DC kh\u00f4ng r\u1ee7i ro<\/li>\n<\/ol>\n

        Vi\u1ec7c kh\u00f4ng ti\u1ebfp c\u1eadn \u0111\u00fang ngu\u1ed3n tin c\u00f3 th\u1ec3 khi\u1ebfn ng\u01b0\u1eddi b\u1ec7nh:<\/p>\n

          \n
        1. <\/span>L\u00e3ng ph\u00ed ti\u1ec1n b\u1ea1c<\/li>\n
        2. <\/span>Ch\u1eadm tr\u1ec5 \u0111i\u1ec1u tr\u1ecb ch\u00ednh th\u1ed1ng<\/li>\n
        3. <\/span>M\u1ea5t ni\u1ec1m tin v\u00e0o y h\u1ecdc<\/li>\n<\/ol>\n

          \ud83d\udcc9 I \u2013 Implication (H\u1ec7 qu\u1ea3):<\/strong> Nguy c\u01a1 khi hi\u1ec3u sai ho\u1eb7c \u00e1p d\u1ee5ng sai<\/h3>\n

          N\u1ebfu ng\u01b0\u1eddi b\u1ec7nh:<\/p>\n

            \n
          1. <\/span>B\u1ecf \u0111i\u1ec1u tr\u1ecb ch\u00ednh th\u1ed1ng<\/li>\n
          2. <\/span>Ch\u1ecdn sai th\u1eddi \u0111i\u1ec3m \u0111\u1ec3 d\u00f9ng mi\u1ec5n d\u1ecbch t\u1ebf b\u00e0o<\/li>\n
          3. <\/span>Nghe theo l\u1eddi truy\u1ec1n mi\u1ec7ng kh\u00f4ng ki\u1ec3m ch\u1ee9ng<\/li>\n<\/ol>\n

            Th\u00ec h\u1eadu qu\u1ea3 c\u00f3 th\u1ec3 l\u00e0:<\/p>\n

              \n
            1. <\/span>Gi\u1ea3m c\u01a1 h\u1ed9i s\u1ed1ng s\u00f3t<\/li>\n
            2. <\/span>Gia \u0111\u00ecnh b\u1ecb \u1ea3nh h\u01b0\u1edfng kinh t\u1ebf<\/li>\n
            3. <\/span>Gi\u1ea3m hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb t\u1ed5ng th\u1ec3<\/li>\n<\/ol>\n

              \u2705 N \u2013 Need (Nhu c\u1ea7u):<\/strong> H\u01b0\u1edbng d\u1eabn \u0111\u00fang \u0111\u1eafn t\u1eeb chuy\u00ean gia y t\u1ebf<\/h3>\n

              Ng\u01b0\u1eddi b\u1ec7nh c\u1ea7n:<\/p>\n

                \n
              1. <\/span>N\u1eafm \u0111\u01b0\u1ee3c b\u1ea3n ch\u1ea5t khoa h\u1ecdc<\/li>\n
              2. <\/span>Bi\u1ebft ai ph\u00f9 h\u1ee3p v\u1edbi ph\u01b0\u01a1ng ph\u00e1p n\u00e0o<\/li>\n
              3. <\/span>Tr\u00e1nh b\u1ecb d\u1eabn d\u1eaft b\u1edfi qu\u1ea3ng c\u00e1o<\/li>\n<\/ol>\n

                SETA Vi\u1ec7t Nam<\/strong> xu\u1ea5t hi\u1ec7n v\u1edbi m\u1ee5c ti\u00eau:<\/p>\n

                  \n
                1. <\/span>Chia s\u1ebb th\u00f4ng tin y h\u1ecdc chu\u1ea9n<\/li>\n
                2. <\/span>Gi\u1ea3i th\u00edch d\u1ec5 hi\u1ec3u c\u00e1c li\u1ec7u ph\u00e1p m\u1edbi<\/li>\n
                3. <\/span>Tr\u1edf th\u00e0nh c\u1ea7u n\u1ed1i y h\u1ecdc hi\u1ec7n \u0111\u1ea1i<\/li>\n<\/ol>\n

                  \ud83d\udd2c \u0110i s\u00e2u t\u1eebng li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch n\u1ed5i b\u1eadt<\/strong><\/h3>\n

                  \ud83d\udd39 Li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch t\u1ef1 nhi\u00ean NK<\/a><\/strong><\/h4>\n
                    \n
                  1. <\/span>L\u00e0 t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch b\u1ea9m sinh, ti\u00eau di\u1ec7t t\u1ebf b\u00e0o l\u1ea1 m\u00e0 kh\u00f4ng c\u1ea7n MHC<\/strong>.<\/li>\n
                  2. <\/span>C\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t b\u1eb1ng IL\u20112, IL\u201115<\/strong> ho\u1eb7c t\u1eeb d\u00f2ng NK\u201192<\/strong>.<\/li>\n
                  3. <\/span>\u1ee8ng d\u1ee5ng: \u0111i\u1ec1u tr\u1ecb th\u1eed nghi\u1ec7m<\/strong> ung th\u01b0 ph\u1ed5i, gan, v\u00fa<\/strong>.<\/li>\n
                  4. <\/span>\u01afu \u0111i\u1ec3m: \u00edt t\u00e1c d\u1ee5ng ph\u1ee5<\/strong>, h\u00e0nh \u0111\u1ed9ng nhanh<\/strong>.<\/li>\n<\/ol>\n

                    \ud83d\udd39 T\u1ebf b\u00e0o T ch\u1ec9nh s\u1eeda gene<\/a><\/strong><\/h4>\n
                      \n
                    1. <\/span>CAR\u2011T<\/strong>: Nh\u1eafm \u0111\u1ebfn kh\u00e1ng nguy\u00ean nh\u01b0 CD19, hi\u1ec7u qu\u1ea3 cao \u1edf ung th\u01b0 m\u00e1u<\/strong>.<\/li>\n
                    2. <\/span>TCR\u2011T<\/strong>: Nh\u1eadn di\u1ec7n kh\u00e1ng nguy\u00ean n\u1ed9i b\u00e0o, m\u1edf r\u1ed9ng ph\u1ea1m vi \u0111i\u1ec1u tr\u1ecb.<\/li>\n
                    3. <\/span>H\u1ea1n ch\u1ebf: chi ph\u00ed cao<\/strong>, d\u1ec5 g\u00e2y CRS<\/strong>, ch\u01b0a hi\u1ec7u qu\u1ea3 v\u1edbi kh\u1ed1i u r\u1eafn<\/strong>.<\/li>\n<\/ol>\n

                      \ud83d\udd39 Vaccine t\u1ebf b\u00e0o DC<\/a><\/strong><\/h4>\n
                        \n
                      1. <\/span>D\u00f9ng t\u1ebf b\u00e0o DC \u0111\u1ec3 hu\u1ea5n luy\u1ec7n h\u1ec7 mi\u1ec5n d\u1ecbch<\/strong> nh\u1eadn di\u1ec7n t\u1ebf b\u00e0o ung th\u01b0.<\/li>\n
                      2. <\/span>Hi\u1ec7u qu\u1ea3: t\u1ea1o mi\u1ec5n d\u1ecbch ghi nh\u1edb<\/strong>, k\u00e9o d\u00e0i th\u1eddi gian s\u1ed1ng.<\/li>\n
                      3. <\/span>\u0110ang th\u1eed nghi\u1ec7m \u1edf ung th\u01b0 gan, ph\u1ed5i, tuy\u1ebfn ti\u1ec1n li\u1ec7t<\/strong>.<\/li>\n<\/ol>\n

                        \ud83d\udce2 V\u00ec sao n\u00ean theo d\u00f5i SETA?<\/h3>\n
                          \n
                        1. <\/span>Th\u00f4ng tin trung l\u1eadp, r\u00f5 r\u00e0ng<\/li>\n
                        2. <\/span>\u0110\u1ed9i ng\u0169 y t\u1ebf, bi\u00ean t\u1eadp chuy\u00ean s\u00e2u<\/li>\n
                        3. <\/span>CAR\u2011NK, vaccine DC th\u1ebf h\u1ec7 m\u1edbi, \u0111i\u1ec1u tr\u1ecb ph\u1ed1i h\u1ee3p \u0111a t\u1ebf b\u00e0o<\/li>\n<\/ol>\n

                          \ud83e\udde0 K\u1ebft lu\u1eadn<\/strong><\/h3>\n

                          Li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch t\u1ebf b\u00e0o NK, T v\u00e0 vaccine DC l\u00e0 h\u01b0\u1edbng \u0111i \u0111\u1ea7y ti\u1ec1m n\u0103ng trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00e0 t\u0103ng c\u01b0\u1eddng h\u1ec7 mi\u1ec5n d\u1ecbch. Tuy nhi\u00ean, s\u1ef1 t\u1ec9nh t\u00e1o v\u00e0 hi\u1ec3u bi\u1ebft l\u00e0 \u0111i\u1ec1u c\u1ea7n thi\u1ebft.<\/p>\n

                          SETAVN<\/a><\/strong> s\u1ebd \u0111\u1ed3ng h\u00e0nh c\u00f9ng b\u1ea1n, gi\u00fap b\u1ea1n khai ph\u00e1 tri th\u1ee9c y t\u1ebf m\u1ed9t c\u00e1ch an to\u00e0n.<\/p>\n","protected":false},"excerpt":{"rendered":"

                          T\u00f3m t\u1eaft: B\u00e0i vi\u1ebft n\u00e0y s\u1ebd gi\u00fap b\u1ea1n hi\u1ec3u r\u00f5 c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng, \u1ee9ng d\u1ee5ng l\u00e2m s\u00e0ng v\u00e0 ti\u1ec1m n\u0103ng c\u1ee7a c\u00e1c li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch t\u1ebf b\u00e0o nh\u01b0 NK, CAR\u2011T\/TCR\u2011T v\u00e0 vaccine t\u1ebf b\u00e0o DC. B\u00e0i vi\u1ebft \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf theo m\u00f4 h\u00ecnh SPIN \u2013 gi\u00fap ng\u01b0\u1eddi \u0111\u1ecdc nh\u1eadn di\u1ec7n r\u00f5 t\u00ecnh hu\u1ed1ng, […]\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1638","post","type-post","status-publish","format-standard","hentry","category-khong-phan-loai"],"_links":{"self":[{"href":"https:\/\/tiengduc1kem1.edu.vn\/index.php\/wp-json\/wp\/v2\/posts\/1638","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/tiengduc1kem1.edu.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/tiengduc1kem1.edu.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/tiengduc1kem1.edu.vn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/tiengduc1kem1.edu.vn\/index.php\/wp-json\/wp\/v2\/comments?post=1638"}],"version-history":[{"count":0,"href":"https:\/\/tiengduc1kem1.edu.vn\/index.php\/wp-json\/wp\/v2\/posts\/1638\/revisions"}],"wp:attachment":[{"href":"https:\/\/tiengduc1kem1.edu.vn\/index.php\/wp-json\/wp\/v2\/media?parent=1638"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/tiengduc1kem1.edu.vn\/index.php\/wp-json\/wp\/v2\/categories?post=1638"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/tiengduc1kem1.edu.vn\/index.php\/wp-json\/wp\/v2\/tags?post=1638"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}