{"id":1668,"date":"2025-06-29T20:05:28","date_gmt":"2025-06-29T20:05:28","guid":{"rendered":"https:\/\/tiengduc1kem1.edu.vn\/index.php\/2025\/06\/29\/3003-giai-ma-cac-lieu-phap-te-bao-mien-dich-nk-t-va-vaccine-dc-xu-huong-moi-trong-y-hoc-ung-thu-hien-dai\/"},"modified":"2025-06-29T20:05:28","modified_gmt":"2025-06-29T20:05:28","slug":"3003-giai-ma-cac-lieu-phap-te-bao-mien-dich-nk-t-va-vaccine-dc-xu-huong-moi-trong-y-hoc-ung-thu-hien-dai","status":"publish","type":"post","link":"https:\/\/tiengduc1kem1.edu.vn\/index.php\/2025\/06\/29\/3003-giai-ma-cac-lieu-phap-te-bao-mien-dich-nk-t-va-vaccine-dc-xu-huong-moi-trong-y-hoc-ung-thu-hien-dai\/","title":{"rendered":"Gi\u1ea3i m\u00e3 c\u00e1c li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch NK, T v\u00e0 vaccine DC: Xu h\u01b0\u1edbng m\u1edbi trong y h\u1ecdc ung th\u01b0 hi\u1ec7n \u0111\u1ea1i"},"content":{"rendered":"

T\u00f3m t\u1eaft:<\/strong> B\u00e0i vi\u1ebft n\u00e0y cung c\u1ea5p cho b\u1ea1n hi\u1ec3u r\u00f5 c\u00e1ch ho\u1ea1t \u0111\u1ed9ng, l\u1ee3i \u00edch v\u00e0 \u1ee9ng d\u1ee5ng c\u1ee7a c\u00e1c li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch t\u1ebf b\u00e0o nh\u01b0 NK, CAR\u2011T\/TCR\u2011T v\u00e0 vaccine t\u1ebf b\u00e0o DC. B\u00e0i vi\u1ebft \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf theo m\u00f4 h\u00ecnh SPIN \u2013 gi\u00fap ng\u01b0\u1eddi \u0111\u1ecdc nh\u1eadn di\u1ec7n r\u00f5 t\u00ecnh hu\u1ed1ng, v\u1ea5n \u0111\u1ec1, h\u1ec7 qu\u1ea3 v\u00e0 nhu c\u1ea7u th\u1ef1c s\u1ef1 khi t\u00ecm hi\u1ec3u c\u00e1c li\u1ec7u ph\u00e1p m\u1edbi trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0.<\/p>\n

<\/p>\n

Kh\u00e1m ph\u00e1 Li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch SETAVN<\/a><\/p>\n

\ud83e\uddec S \u2013 Situation (T\u00ecnh hu\u1ed1ng hi\u1ec7n t\u1ea1i):<\/strong> Nhu c\u1ea7u t\u00ecm hi\u1ec3u li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch t\u0103ng cao<\/h3>\n

Trong nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y, c\u00e1c kh\u00e1i ni\u1ec7m nh\u01b0:<\/p>\n

    \n
  1. <\/span>\u201cMi\u1ec5n d\u1ecbch tr\u1ecb li\u1ec7u cho ung th\u01b0\u201d<\/li>\n
  2. <\/span>\u201cC\u00e1ch ho\u1ea1t \u0111\u1ed9ng c\u1ee7a vaccine t\u1ebf b\u00e0o DC\u201d<\/li>\n
  3. <\/span>\u201cCAR\u2011T c\u00f3 th\u1ef1c s\u1ef1 hi\u1ec7u qu\u1ea3?\u201d<\/li>\n<\/ol>\n

    …\u0111ang \u0111\u01b0\u1ee3c t\u00ecm ki\u1ebfm r\u1ed9ng r\u00e3i. \u0110i\u1ec1u n\u00e0y cho th\u1ea5y s\u1ef1 quan t\u00e2m m\u1ea1nh m\u1ebd t\u1eeb c\u1ed9ng \u0111\u1ed3ng b\u1ec7nh nh\u00e2n v\u00e0 ng\u01b0\u1eddi th\u00e2n v\u1ec1 c\u00e1c li\u1ec7u ph\u00e1p nh\u01b0:<\/p>\n

      \n
    1. <\/span>T\u1ebf b\u00e0o NK \u2013 s\u00e1t th\u1ee7 t\u1ef1 nhi\u00ean<\/li>\n
    2. <\/span>T\u1ebf b\u00e0o T t\u00e1i l\u1eadp theo c\u00f4ng ngh\u1ec7 cao<\/li>\n
    3. <\/span>Li\u1ec7u ph\u00e1p hu\u1ea5n luy\u1ec7n h\u1ec7 mi\u1ec5n d\u1ecbch<\/li>\n<\/ol>\n

      \u26a0\ufe0f P \u2013 Problem (V\u1ea5n \u0111\u1ec1):<\/strong> K\u1ef3 v\u1ecdng sai l\u1ec7ch v\u1ec1 mi\u1ec5n d\u1ecbch t\u1ebf b\u00e0o<\/h3>\n

      D\u00f9 th\u00f4ng tin tr\u00e0n lan, nh\u01b0ng nhi\u1ec1u ng\u01b0\u1eddi v\u1eabn:<\/p>\n

        \n
      1. <\/span>T\u01b0\u1edfng li\u1ec7u ph\u00e1p NK c\u00f3 th\u1ec3 ch\u1eefa m\u1ecdi lo\u1ea1i ung th\u01b0<\/li>\n
      2. <\/span>Cho r\u1eb1ng CAR\u2011T \u00e1p d\u1ee5ng cho t\u1ea5t c\u1ea3 ung th\u01b0<\/li>\n
      3. <\/span>So s\u00e1nh vaccine DC v\u1edbi vaccine ti\u00eam ng\u1eeba th\u01b0\u1eddng<\/li>\n<\/ol>\n

        Vi\u1ec7c kh\u00f4ng ti\u1ebfp c\u1eadn \u0111\u00fang ngu\u1ed3n tin c\u00f3 th\u1ec3 khi\u1ebfn ng\u01b0\u1eddi b\u1ec7nh:<\/p>\n

          \n
        1. <\/span>L\u00e3ng ph\u00ed ti\u1ec1n b\u1ea1c<\/li>\n
        2. <\/span>B\u1ecf l\u1ee1 th\u1eddi \u0111i\u1ec3m \u0111i\u1ec1u tr\u1ecb hi\u1ec7u qu\u1ea3<\/li>\n
        3. <\/span>T\u1ed5n th\u01b0\u01a1ng t\u00e2m l\u00fd<\/li>\n<\/ol>\n

          \ud83d\udcc9 I \u2013 Implication (H\u1ec7 qu\u1ea3):<\/strong> \u0110i\u1ec1u g\u00ec x\u1ea3y ra n\u1ebfu ti\u1ebfp c\u1eadn sai ph\u01b0\u01a1ng ph\u00e1p?<\/h3>\n

          N\u1ebfu ng\u01b0\u1eddi b\u1ec7nh:<\/p>\n

            \n
          1. <\/span>B\u1ecf \u0111i\u1ec1u tr\u1ecb ch\u00ednh th\u1ed1ng<\/li>\n
          2. <\/span>Ch\u1ecdn sai th\u1eddi \u0111i\u1ec3m \u0111\u1ec3 d\u00f9ng mi\u1ec5n d\u1ecbch t\u1ebf b\u00e0o<\/li>\n
          3. <\/span>\u0110\u1eb7t ni\u1ec1m tin v\u00e0o qu\u1ea3ng c\u00e1o sai l\u1ec7ch<\/li>\n<\/ol>\n

            Th\u00ec h\u1eadu qu\u1ea3 c\u00f3 th\u1ec3 l\u00e0:<\/p>\n

              \n
            1. <\/span>Gi\u1ea3m c\u01a1 h\u1ed9i s\u1ed1ng s\u00f3t<\/li>\n
            2. <\/span>Gia \u0111\u00ecnh b\u1ecb \u1ea3nh h\u01b0\u1edfng kinh t\u1ebf<\/li>\n
            3. <\/span>Kh\u00f3 quay l\u1ea1i \u0111i\u1ec1u tr\u1ecb \u0111\u00fang ph\u00e1c \u0111\u1ed3<\/li>\n<\/ol>\n

              \u2705 N \u2013 Need (Nhu c\u1ea7u):<\/strong> H\u01b0\u1edbng d\u1eabn \u0111\u00fang \u0111\u1eafn t\u1eeb chuy\u00ean gia y t\u1ebf<\/h3>\n

              Ng\u01b0\u1eddi b\u1ec7nh c\u1ea7n:<\/p>\n

                \n
              1. <\/span>Hi\u1ec3u r\u00f5 c\u01a1 ch\u1ebf t\u1eebng li\u1ec7u ph\u00e1p<\/li>\n
              2. <\/span>Bi\u1ebft ai ph\u00f9 h\u1ee3p v\u1edbi ph\u01b0\u01a1ng ph\u00e1p n\u00e0o<\/li>\n
              3. <\/span>\u0110\u01b0\u1ee3c t\u01b0 v\u1ea5n t\u1eeb ngu\u1ed3n \u0111\u00e1ng tin<\/li>\n<\/ol>\n

                SETA Vi\u1ec7t Nam<\/strong> ra \u0111\u1eddi v\u1edbi m\u1ee5c ti\u00eau:<\/p>\n

                  \n
                1. <\/span>Chia s\u1ebb th\u00f4ng tin y h\u1ecdc chu\u1ea9n<\/li>\n
                2. <\/span>Gi\u1ea3i th\u00edch d\u1ec5 hi\u1ec3u c\u00e1c li\u1ec7u ph\u00e1p m\u1edbi<\/li>\n
                3. <\/span>\u0110\u1ed3ng h\u00e0nh c\u00f9ng b\u1ec7nh nh\u00e2n trong h\u00e0nh tr\u00ecnh \u0111i\u1ec1u tr\u1ecb<\/li>\n<\/ol>\n

                  \ud83d\udd2c \u0110i s\u00e2u t\u1eebng li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch n\u1ed5i b\u1eadt<\/strong><\/h3>\n

                  \ud83d\udd39 C\u00e1ch tr\u1ecb li\u1ec7u b\u1eb1ng t\u1ebf b\u00e0o NK<\/a><\/strong><\/h4>\n
                    \n
                  1. <\/span>L\u00e0 t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch b\u1ea9m sinh, ti\u00eau di\u1ec7t t\u1ebf b\u00e0o l\u1ea1 m\u00e0 kh\u00f4ng c\u1ea7n MHC<\/strong>.<\/li>\n
                  2. <\/span>C\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t b\u1eb1ng IL\u20112, IL\u201115<\/strong> ho\u1eb7c t\u1eeb d\u00f2ng NK\u201192<\/strong>.<\/li>\n
                  3. <\/span>\u1ee8ng d\u1ee5ng: \u0111i\u1ec1u tr\u1ecb th\u1eed nghi\u1ec7m<\/strong> ung th\u01b0 ph\u1ed5i, gan, v\u00fa<\/strong>.<\/li>\n
                  4. <\/span>\u01afu \u0111i\u1ec3m: \u00edt t\u00e1c d\u1ee5ng ph\u1ee5<\/strong>, h\u00e0nh \u0111\u1ed9ng nhanh<\/strong>.<\/li>\n<\/ol>\n

                    \ud83d\udd39 Li\u1ec7u ph\u00e1p ch\u1ec9nh s\u1eeda gene t\u1ebf b\u00e0o T<\/a><\/strong><\/h4>\n
                      \n
                    1. <\/span>CAR\u2011T<\/strong>: Nh\u1eafm \u0111\u1ebfn kh\u00e1ng nguy\u00ean nh\u01b0 CD19, hi\u1ec7u qu\u1ea3 cao \u1edf ung th\u01b0 m\u00e1u<\/strong>.<\/li>\n
                    2. <\/span>TCR\u2011T<\/strong>: Nh\u1eadn di\u1ec7n kh\u00e1ng nguy\u00ean n\u1ed9i b\u00e0o, m\u1edf r\u1ed9ng ph\u1ea1m vi \u0111i\u1ec1u tr\u1ecb.<\/li>\n
                    3. <\/span>H\u1ea1n ch\u1ebf: chi ph\u00ed cao<\/strong>, d\u1ec5 g\u00e2y CRS<\/strong>, ch\u01b0a hi\u1ec7u qu\u1ea3 v\u1edbi kh\u1ed1i u r\u1eafn<\/strong>.<\/li>\n<\/ol>\n

                      \ud83d\udd39 Vaccine DC \u0111i\u1ec1u tr\u1ecb ung th\u01b0<\/a><\/strong><\/h4>\n
                        \n
                      1. <\/span>D\u00f9ng t\u1ebf b\u00e0o DC \u0111\u1ec3 hu\u1ea5n luy\u1ec7n h\u1ec7 mi\u1ec5n d\u1ecbch<\/strong> nh\u1eadn di\u1ec7n t\u1ebf b\u00e0o ung th\u01b0.<\/li>\n
                      2. <\/span>Hi\u1ec7u qu\u1ea3: t\u1ea1o mi\u1ec5n d\u1ecbch ghi nh\u1edb<\/strong>, k\u00e9o d\u00e0i th\u1eddi gian s\u1ed1ng.<\/li>\n
                      3. <\/span>\u0110ang th\u1eed nghi\u1ec7m \u1edf ung th\u01b0 gan, ph\u1ed5i, tuy\u1ebfn ti\u1ec1n li\u1ec7t<\/strong>.<\/li>\n<\/ol>\n

                        \ud83d\udce2 SETA mang \u0111\u1ebfn g\u00ec cho c\u1ed9ng \u0111\u1ed3ng?<\/h3>\n
                          \n
                        1. <\/span>Kh\u00f4ng qu\u1ea3ng b\u00e1 sai l\u1ec7ch, kh\u00f4ng th\u1ea7n th\u00e1nh h\u00f3a li\u1ec7u ph\u00e1p<\/li>\n
                        2. <\/span>K\u1ebft n\u1ed1i v\u1edbi b\u00e1c s\u0129 chuy\u00ean khoa \u0111\u1ea7u ng\u00e0nh<\/li>\n
                        3. <\/span>CAR\u2011NK, vaccine DC th\u1ebf h\u1ec7 m\u1edbi, \u0111i\u1ec1u tr\u1ecb ph\u1ed1i h\u1ee3p \u0111a t\u1ebf b\u00e0o<\/li>\n<\/ol>\n

                          \ud83e\udde0 K\u1ebft lu\u1eadn<\/strong><\/h3>\n

                          Li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch t\u1ebf b\u00e0o NK, T v\u00e0 vaccine DC l\u00e0 b\u01b0\u1edbc ti\u1ebfn v\u01b0\u1ee3t b\u1eadc trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00e0 t\u0103ng c\u01b0\u1eddng h\u1ec7 mi\u1ec5n d\u1ecbch. Tuy nhi\u00ean, hi\u1ec3u \u0111\u00fang, ch\u1ecdn \u0111\u00fang v\u00e0 d\u00f9ng \u0111\u00fang l\u00e0 \u0111i\u1ec1u c\u1ea7n thi\u1ebft.<\/p>\n

                          SETA<\/a><\/strong> s\u1ebd \u0111\u1ed3ng h\u00e0nh c\u00f9ng b\u1ea1n, gi\u00fap b\u1ea1n khai ph\u00e1 tri th\u1ee9c y t\u1ebf m\u1ed9t c\u00e1ch hi\u1ec7u qu\u1ea3.<\/p>\n","protected":false},"excerpt":{"rendered":"

                          T\u00f3m t\u1eaft: B\u00e0i vi\u1ebft n\u00e0y cung c\u1ea5p cho b\u1ea1n hi\u1ec3u r\u00f5 c\u00e1ch ho\u1ea1t \u0111\u1ed9ng, l\u1ee3i \u00edch v\u00e0 \u1ee9ng d\u1ee5ng c\u1ee7a c\u00e1c li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch t\u1ebf b\u00e0o nh\u01b0 NK, CAR\u2011T\/TCR\u2011T v\u00e0 vaccine t\u1ebf b\u00e0o DC. B\u00e0i vi\u1ebft \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf theo m\u00f4 h\u00ecnh SPIN \u2013 gi\u00fap ng\u01b0\u1eddi \u0111\u1ecdc nh\u1eadn di\u1ec7n r\u00f5 t\u00ecnh hu\u1ed1ng, v\u1ea5n \u0111\u1ec1, […]\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1668","post","type-post","status-publish","format-standard","hentry","category-khong-phan-loai"],"_links":{"self":[{"href":"https:\/\/tiengduc1kem1.edu.vn\/index.php\/wp-json\/wp\/v2\/posts\/1668","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/tiengduc1kem1.edu.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/tiengduc1kem1.edu.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/tiengduc1kem1.edu.vn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/tiengduc1kem1.edu.vn\/index.php\/wp-json\/wp\/v2\/comments?post=1668"}],"version-history":[{"count":0,"href":"https:\/\/tiengduc1kem1.edu.vn\/index.php\/wp-json\/wp\/v2\/posts\/1668\/revisions"}],"wp:attachment":[{"href":"https:\/\/tiengduc1kem1.edu.vn\/index.php\/wp-json\/wp\/v2\/media?parent=1668"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/tiengduc1kem1.edu.vn\/index.php\/wp-json\/wp\/v2\/categories?post=1668"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/tiengduc1kem1.edu.vn\/index.php\/wp-json\/wp\/v2\/tags?post=1668"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}